Maestro Pro, 768-channel electrode-based assay system for MEA and impedance applications. Axion

• Measure cellular activity label-free and real-time – The Maestro Pro detects key parameters of neural network activity, cardiac functionality, and cell growth, death and attachment.
• Precisely control the cells environment – Cells are a product of their environment. Maestro Pro has a smart environmental chamber that finely controls temperature and CO₂ while rejecting electrical noise and mechanical vibrations.
• Connect to your network – 768 simultaneous live recordings from your cells with the Neural and Cardiac modules. Now you can understand life’s circuitry label free in real time in 6-, 24-, 48-, or 96-well plates.
• Continuous cell monitoring – 384 simultaneous live recordings from your cells with the Impedance module.  Track cell proliferation, morphology, and viability in real-time in 96- or 384-well plates.
• See your cells – Sometimes you just want to look at your cells under a microscope. Maestro’s CytoView patented transparent circuit technology allows cell visualization and assay multiplexing.
• Control cellular activity – Recreate specific patterns of cellular activity using electrical stimulation or light pulses (with the Lumos optical stimulation system)
• Start your assay with the push of a button – “One button setup,” means temperature and CO₂ levels automatically adjust on plate docking. Plate usage is logged via an integrated plate barcode scanner for convenient experiment tracking.
• Monitor the kinetics of your biology on your smartphone – No need to be in lab. With the Impedance module, track changes in cell proliferation, viability, and cell killing over minutes or weeks.

The complete multiwell MEA system

The evaluation of electrically-active cells has historically been tedious, requiring months of training to painstakingly study single cells in low throughputs. By culturing a network of cells over the high electrode count arrays available in each well of our MEA plates, Axion BioSystems’ Maestro Pro multiwell MEA system captures activity across an entire population of cells, with far greater data points per well, detecting activity patterns that would otherwise elude traditional assays. Axion’s contribution to establishing microelectrode array (MEA) technology as an accessible, versatile research tool cannot be defined by a single advantage. It’s the cumulative effect of our commitment to growing our multiwell MEA system to include instruments, accessories and software working in unison.

…and impedance system, all in one platform

Cell-based assays enable rapid evaluation of human biology in vitro, with substantial advantages in throughput and cost over tissue or animal models. However, many cell-based assays are endpoint assays, limited to a single snapshot in time. Axion BioSystems’ Maestro Pro platform also offers impedance-based cell analysis for real-time, continuous, label-free monitoring of your cells. Continuous data reveals the kinetics of cell-cell interactions and cell-drug responses for better mechanistic understanding without the time- and cost-intensive process of repeating multiple endpoint assays.