Description
Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.
Species Reactivity
Human, Mouse, Rat
Specificity
The antibody detects endogenous levels of Tau only when phosphorylated at threonione 217.
Purity/Purification
Affinity purification
Concentration
1.0 mg/ml (lot specific)
Immunogen Type
Peptide-KLH
Immunogen
Peptide sequence around phosphorylation site of threonine 217(L-P-T(p)-P-P) derived from Human Tau.
Preparation and Storage
Store at -20°C. Avoid freeze/thaw cycles.
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